杨婧;刘杨颖秋;刘娜;高冰冰;宋清伟;张浩南;苗延巍;

• 1:大连医科大学附属第一医院放射科

摘要(Abstract)：

目的 比较不同脑压缩感知(compressed sensing,CS)磁敏感加权成像(susceptibility weighted imaging,SWI)的加速因子(acceleration factor,AF)对中脑“燕尾征(swallow tail sign, STS)”显示及定量的影响，寻找最佳AF。材料与方法 前瞻性征募40名健康志愿者进行头部3.0 T MRI检查，包括CS-SWI序列(AF=0及CS2、CS4、CS6、CS8、CS10)。对SWI的相位图像进行观察和测量，计数不同AF中STS显示数量。测量相位值(phase value,PV)并计算信噪比(signal to noise ratio,SNR)及对比噪声比(contrast to noise ratio,CNR)。采用Cohen's Kappa分析评估黑质(substantia nigra,SN)和STS主观评价的组间一致性；通过计算组内相关系数(interclass correlation cofficient,ICC)，验证PV值和主观评分的一致性。运用Fisher确切概率法分析不同AF下STS显示率的差异。使用单因素方差分析(analysis of variance,ANOVA)中最小显著性差异法(least-significant difference,LSD)对比不同AF条件下SN和STS图像质量的差异。P值经Benjamini-Hochberg的错误发现率(false discovery rate,FDR)法校正，P<0.05认为差异具有统计学意义。结果 2名观察者间的主观评分一致性极好(Kappa>0.80)。PV值测量和主观评分的组内一致性极好(ICC>0.80)。当AF≥6时，STS图像表现为清晰度明显下降，且STS的显示率降低，差异具有统计学意义(P<0.05)。双侧SNs的SNR和CNR在AF>2时差异具有统计学意义(P<0.05)。双侧STSs的SNR和CNR在AF>4时差异具有统计学意义(P<0.05)。结论 由脑SWI图像定量数据结果可知，对STS结构的观察可根据SNR、CNR以及主观评分和显示率变化，可考虑CS4，扫描时间减少4 min 9 s (70.7%)。

关键词(KeyWords)： 磁敏感加权成像;压缩感知;燕尾征;加速因子;图像质量

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(编号：81671646);; 大连市科技创新基金计划(编号：2020JJ27SN075)~~

作者(Authors): 杨婧;刘杨颖秋;刘娜;高冰冰;宋清伟;张浩南;苗延巍;

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