杨旭宏;黄雪莹;刘文潇;王明磊;葛鑫;张伟;党佩;丁向春;王晓东;

• 1:宁夏医科大学临床医学院
• 2:宁夏医科大学总医院放射科
• 3:宁夏医科大学总医院感染疾病科
• 4:宁夏医科大学颅脑疾病重点实验室

摘要(Abstract)：

目的 探究轻微型肝性脑病(minimal hepatic encephalopathy,MHE)患者脑区局部一致性(regional homogeneity,ReHo)改变对认知功能的影响。材料与方法 前瞻性纳入25例乙肝肝硬化伴MHE患者(MHE组)、27例无MHE的乙肝肝硬化患者(肝硬化组)和30例性别、年龄、受教育程度相匹配的健康对照者(健康对照组)。所有受试者均行颅脑静息态血氧水平依赖功能磁共振成像(blood oxygenation level-dependent functional magnetic resonance imaging,BOLD-fMRI)扫描，将原始图像经过处理后得到ReHo脑图，用独立样本t检验分别比较健康对照组、肝硬化组和MHE组三组之间ReHo差异的脑区。采用Person相关分析法分析MHE组脑区ReHo与蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评分的相关性。结果 与健康对照组和肝硬化组相比，MHE组数字连接试验A (Number Connection Test-A,NCT-A)量表评分显著升高、数字符号试验(Digital Symbol Test,DST)及MoCA评分降低，差异均有统计学意义(P<0.01)。与健康对照相比，MHE组右侧额中回、颞中回、颞下回及双侧中央旁小叶的ReHo显著降低，左侧楔前叶ReHo升高，差异均有统计学意义(P<0.05)。相关分析显示MHE组MoCA评分与左侧中央前回、左侧颞中回及部分枕部的平均ReHo值呈负相关(P<0.05)，与右侧缘上回的平均ReHo值呈正相关(P<0.05)。结论 MHE患者认知障碍的发生可能与脑区ReHo的改变有关。

关键词(KeyWords)： 轻微型肝性脑病;认知功能;局部一致性;血氧水平依赖;功能磁共振成像;数字连接实验A;数字符号实验

Abstract:

Keywords:

基金项目(Foundation): 宁夏自然科学基金(编号：2022AAC03487);; 宁夏回族自治区科技重点研究计划(编号：2019BEG03037);; 宁夏医科大学颅脑疾病重点实验室神经科学优势学科群(编号：LNKF202109)~~

作者(Authors): 杨旭宏;黄雪莹;刘文潇;王明磊;葛鑫;张伟;党佩;丁向春;王晓东;

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